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New York Times on CALERIE

A look at present human studies of the health benefits of calorie restriction at the New York Times: “As Americans become fatter and fatter - a study published in July revealed that obesity rates increased in 23 states last year and declined in none - a select group of men and women under the watchful care of medical professionals have spent the past few years becoming thinner and thinner. There are 132 of them, located in and around Boston, St. Louis and Baton Rouge, La. All are enrolled in a large clinical trial that is financed by the National Institutes of Health and known as Calerie, which stands for Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy. … the Calerie project [is] that it is not meant to study weight loss or if one type of diet is better than another. Instead, Calerie is investigating how (and if) a spartan diet affects the aging process and its associated diseases. To the Calerie researchers, these are quite distinct. The aging process, which researchers sometimes call ‘primary’ or ‘intrinsic’ aging, refers to the damage that ordinarily accumulates in our cells as we grow older, a natural condition that seems to have limited the maximal lifespan of humans to 120 years. Diseases that accompany the aging process - often called ’secondary aging’ - are those afflictions increasingly prevalent in the elderly, like cancer, diabetes and cardiovascular disease.”

View the Article Under Discussion: http://www.nytimes.com/2009/10/11/magazine/11Calories-t.html?pagewanted=print

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

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h+ Magazine on Anti-Cancer Nanotechnology

A look at the state of the art in cancer therapies under development from h+ Magazine: "Nanomedicine, an offshoot of nanotechnology, refers to highly specific medical intervention at the molecular scale for curing disease or repairing damaged tissues, such as bone, muscle, nerve, or brain cells. Nanoparticles - anywhere from 100 to 2500 nanometers in size - are at the same scale as the biological molecules and structures inside living cells. ... Titanium dioxide is not the only nanoparticle that shows promise in cancer therapy. Gold nanospheres - nearly perfectly spherical nanoparticles that range in size from 30 to 50 nanometers - are being used to search out and 'cook' cancer cells. The cancer-destroying nanospheres show promise as a minimally invasive future treatment for malignant melanoma, the most serious form of skin cancer. ... The hollow gold nanospheres are equipped with a special peptide that draws the nanospheres directly to melanoma cells, while avoiding healthy skin cells. After collecting inside the cancer, the nanospheres heat up when exposed to near-infrared light, which penetrates deeply through the surface of the skin."


View the Article Under Discussion: http://hplusmagazine.com/articles/nano/targeting-cancer-cells-nanoparticles
Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

The Pursuit of Cryonics as Medicine

From Depressed Metabolism: "The biggest obstacle to the acceptance of cryonics is medical myopia; the idea that someone who has been pronounced dead by contemporary medical criteria will still be considered dead by future criteria. Advocates of human cryopreservation strongly argue against this. There are few things more discomforting than the idea that medical professionals of the future will look back in horror and wonder why we gave up on people who still possessed the neuroanatomical basis of their identities and memories. But there is another kind of myopia in the public discussion of cryonics that warrants consideration. It is taken for granted by some critics of contemporary cryonics that cryonics has always been framed as a form of medicine. Nothing could be further from the truth. The history of cryonics is replete with debates between advocates of the medical model and those who believe that timely transport of the patient to a cryonics facility for low temperature storage should be adequate for future resuscitation by advanced nanotechnology. It is only because cryonics advocates with medical and research backgrounds such as Mike Darwin and Jerry Leaf vigorously argued for adopting conventional medical techniques and protocols that today's cryonics organizations can even be criticized for falling short of these criteria."


View the Article Under Discussion: http://www.depressedmetabolism.com/2009/10/06/the-pursuit-of-cryonics-as-medicine/
Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Singularity Hub on the Mprize

The Singularity Hub here looks at the Mprize for longevity research: "If living forever isn't enough motivation to get scientists to study longevity, maybe $3.8 million will work instead. That's the current size of the Mprize, a special fund put forth by the Methuselah Foundation that seeks to encourage research into extending healthy human life. The prize is awarded to those scientists who can increase the lifespan of lab mice in the hopes that work performed on that species can be readily applied to humans. Can we live longer? Do we even want to? When will the average human life expectancy start to increase by more than a year each year? The Methuselah Foundation's answers are yes, yes, and much sooner than you might think. ... offering a cash prize to help motivate research has a long and successful history. Mariners were finally able to determine their longitude at sea thanks to the aptly named Longitude Prize offered by the British government. Lindbergh's transatlantic flight was in direct response to the Orteig prize. The modern day Xprize is inspiring new achievements in genomics, space flight, lunar exploration, and transportation efficiency. With the Mprize, the Methuselah Foundation may very well bring about a surge in the interest in increasing human lifespans within the next generation."

View the Article Under Discussion: http://singularityhub.com/2009/10/06/mprize-your-children-could-be-immortal/
Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

The “Yuck Factor” and Cryonics

As pointed out at Depressed Metabolism, people don't like to contemplate most medical procedures in any detail: "In sensationalized accounts of cryonics, explicit descriptions of cryonics procedures, and that of neuropreservation in particular, are used to invoke a negative response in the reader. ... In some [other and undesirable aspects of human activity], such as senseless violence, this is not necessarily an unreasonable approach because it may reflect a preserved instinct against behavior that is harmful to the individual or group. ... Where such an appeal to gut feelings is less fruitful, however, is in the context of medicine and forensics. The daily activities of many medical professionals and morticians consist of activities that would produce a strong negative gut response in most people who would observe them in all their detail. ... The 'yuck factor' that is produced in many people when they read about the details of cryonics procedures is not evidence of pseudo-science or mistreatment. As a matter of fact, the procedures that are routinely performed in cryonics labs are designed to preserve life, not to destroy it. In this sense, the practice of cryonics can claim the moral high ground over prevailing methods of dealing with 'human remains,' where [people presently considered dead and gone in the mainstream view] are buried or burned because contemporary medicine has not yet found a way to treat [or restore] them. If anything, it is this kind of medical myopia that should trigger the yuck factor."

View the Article Under Discussion: http://www.depressedmetabolism.com/2009/10/05/the-yuck-factor-and-cryonics/
Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Methuselah Foundation Newsletter, September 2009

The latest Methuselah Foundation newsletter is out: "This month we are introducing the last of the four newest Mprize competitors. Significant cash Prizes are awarded for Longevity, breaking the world record for the oldest-ever mouse, and Rejuvenation, the most successful late-onset rejuvenation of a mouse. The amount won is in proportion to the size of the fund and to the margin by which the previous record is broken. ... Bruce Teter is optimistic about the possibility that curcumin, which is the element of the spice turmeric that gives it its color, will extend the life of mice. ... In addition to the mice at Steve Spindler's lab, three other labs are conducting tests. Those three labs are funded through ITP, the Interventions Testing Program of the National Institute on Aging ... The ITP labs started with 3 month old mice to determine if curcumin intervention mimics the effects of Calorie Restriction in extending life. Steve's lab started with 12 month old mice and will measure the effects of a unique preparation of curcumin to extend maximal lifespan with late-life treatment."

View the Article Under Discussion: http://blog.methuselahfoundation.org/2009/10/methuselah_foundation_newslett_5.html
Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/